Results
| PMID | 22017422 |
| Gene Name | GSTM1 |
| Condition | Endometriosis |
| Association |
Associated |
| Sex | Female |
| Associated genes | CYP1A1, CYP1B1, GSTM1, GSTT1, GSTP1, AhR, ARNT, and AhRR |
| Other associated phenotypes |
Endometriosis |
|
Am J Reprod Immunol. 2012 Feb;67(2):160-8. doi: 10.1111/j.1600-0897.2011.01077.x. Wu, Cheng-Hsuan| Guo, Chao-Yu| Yang, Jyuer-Ger| Tsai, Horng-Der| Chang, Yu-Jun| Tsai, Pei-Chien| Hsu, Chao-Chin| Kuo, Pao-Lin Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan. PROBLEM: To establish a multilocus model for studying the effect of dioxin receptor complex components and detoxification-related enzymes on advanced endometriosis. METHOD OF STUDY: Six single-nucleotide polymorphisms (SNPs) and two deletion polymorphisms from eight genes (CYP1A1, CYP1B1, GSTM1, GSTT1, GSTP1, AhR, ARNT, and AhRR) were genotyped. RESULTS: In the single SNP analysis, GSTM1 null type and AhRR variant type were associated with a significantly increased risk of endometriosis [odds ratio (OR)=2.38 and 2.45, respectively]. Using multiple SNPs in the logistic regression for covariates, wild-type AhR and mutant AhRR combination was significantly higher in patients (67.8%) than in controls (48.0%) (OR=2.76). On the other hand, mutant AhRR in combination with GSTM1 null genotype was significantly higher in patients (35.5%) than in controls (19.3%) (OR=6.12). CONCLUSION: Polymorphisms of dioxin receptor complex components and detoxification-related genes jointly confer susceptibility to advanced-stage endometriosis in the Taiwanese Han population. Mesh Terms: Adult| Basic Helix-Loop-Helix Transcription Factors/*genetics| Case-Control Studies| Endometriosis/*genetics| Female| Genetic Predisposition to Disease| Genotype| Glutathione Transferase/*genetics| Humans| Polymorphism, Single Nucleotide| Recept |
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